README ====== Dataset title: Data for "Hypergammaglobulinemia in treated and untreated people with HIV" Creators: Isabel Vigmo, Magnus Gisslén, Johanna Karlsson, Josefina Robertson Responsible organization: University of Gothenburg, Sweden See the Researchdata.se catalogue entry for this dataset for complete metadata, including the dataset description, recommended citation, contact information, and information about how to obtain the dataset. Description: The dataset contains information on sex, age, serum/plasma levels of IgG, neopterin, β2-microglobulin, albumin, HIV-RNA (when applicable), CD4+, CD4+ nadir, antiretroviral therapy, duration of viral suppression and hepatitis C status in a cohort of people with HIV and an HIV-negative control group. Access restrictions: This dataset contains pseudoanonymized data and is subject to legal protections. This dataset can be requested from the Researchdata.se research data catalog. Essential information for dataset reuse. ---------------------------------------- The samples from the HIV-positive participants are categorized according to eight categories representing immunologically different stages of HIV infection: primary HIV infection (PHI; within 12 months of initial HIV infection), five groups characterized by CD4+ T cell counts (≥ 500; 350−499; 200−349, 50−199 and < 50 cells/μL), ongoing infection or malignancy (OIM), and those on ART. The diagnosis of PHI was based on a combination of clinical histories and seroconversion, nucleic acid testing or enzyme-linked immunosorbent assay (ELISA) testing. OIM was defined as the presence of an opportunistic or non-opportunistic bacterial, viral or parasitic infection or active cancer in association with or within two weeks of blood sampling. ART suppression was defined as ongoing ART with plasma HIV-RNA < 50 copies/mL for ≥ 6 months and included antiretroviral regimens with two or more active agents (non-nucleoside reverse transcriptase inhibitors, nucleoside reverse transcriptase inhibitors, integrase inhibitors and/or protease inhibitors) according to guidelines existing at the time of inclusion. Datafile descriptions ---------------------- The dataset "dataset_hypergammaglobulinemia" contains the variables listed below. Age Years Gender 0, male; 1, female Category 0, HIV-negative; 1, PHI; 3, CD4>500; 4, CD4 350-499; 5, CD4 200-349; 6, CD4 50-199; 7, CD4 <50; 10, OIM; 22, ART CD4 nadir cells/ µL ART Individual description for each participant on ART HIV-RNA copies/ml CD4 nadir cells/ µL Beta-2-microglobulin mg/L Neopterin nmol/L IgG g/L Albumin g/L Duration of viral surpression Months between date of viral supression and date of sampling. Hepatitis C 0, negative; 1, positive Reference information --------------------- PHI Primary HIV infection OIM Opportunistic infection or malignancy ART Antiretroviral therapy TDF Tenofovir disoproxil fumarate FTC Emtricitabin Etr Etravirin Drv/r Darunavir/ritonavir Rgv Raltegravir ABC Abacavir 3TC Lamuvidin Ddl Didanosine Efv Efavirenz Zdv Zidovudine Lpv/r Lopinavir/ritonavir Mvc Maraviroc Dgv Dolutegravir D4T Stavudine Azv/r Atazanavir/ritonavir Nfv Nelfinavire Nvp Nevirapine Taf Tenofovir alafenamide Idv Indinavir Sqv Saquinavir Rit Ritonavir Ddc Zalcitabine Evg/c Elvitegravir/cobicistat Sqv-Sgc Saquinavir- soft gel capsule Sqv-Hcg Saquinavir-hard gel capsule Dor Doravirin Rpv Rilpivirin Cbg Cabetogravir Data Quality: Blank cells represent missing data.